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Evaluation of alpelisib-induced hyperglycemia prophylaxis and associated risk factors in PIK3CA-mutated hormone-receptor positive, human epidermal growth factor-2 negative advanced breast cancer.

Sarah E BurnetteEmily PoehleinHui-Jie LeeJeremy ForceKelly WestbrookHeather B Moore
Published in: Breast cancer research and treatment (2022)
Implementation of a HG prophylaxis protocol with ALP in a single-center study demonstrated fewer G3-4 HG events compared to that seen in SOLAR-1 (19% vs 36.6%). An increase in HG-associated risk factors correlated with a higher incidence of G2-4 HG.
Keyphrases
  • growth factor
  • fluorescent probe
  • aqueous solution
  • living cells
  • endothelial cells
  • diabetic rats
  • randomized controlled trial
  • healthcare
  • high glucose
  • primary care
  • risk factors
  • oxidative stress