Reduced gut microbiome protects from alcohol-induced neuroinflammation and alters intestinal and brain inflammasome expression.
Patrick P LoweBenedek GyongyosiAbhishek SatishchandranArvin Iracheta-VellveYeonhee ChoAditya AmbadeGyongyi SzaboPublished in: Journal of neuroinflammation (2018)
Our data show for the first time that the acute-on-chronic alcohol administration in mice induces both neuroinflammation and intestinal inflammation and that reduction in the intestinal bacterial load can attenuate alcohol-associated CNS and gut inflammation. Gut microbiome-derived signals contribute to neuroinflammation in acute-on-chronic alcohol exposure.
Keyphrases
- drug induced
- liver failure
- alcohol consumption
- traumatic brain injury
- lipopolysaccharide induced
- oxidative stress
- cerebral ischemia
- lps induced
- respiratory failure
- cognitive impairment
- poor prognosis
- inflammatory response
- aortic dissection
- diabetic rats
- high glucose
- metabolic syndrome
- adipose tissue
- long non coding rna
- high fat diet induced
- binding protein