Improving drug delivery to the brain: the prodrug approach.
Kristiina M HuttunenPublished in: Expert opinion on drug delivery (2024)
With the expandingly improved analytical and computational technologies, it is anticipated that enhanced brain drug delivery will be eventually achieved for most of the central nervous system (CNS) acting drugs. However, this requires that carrier-mediated (pro)drug delivery methods are implemented in the very early phases of the drug development processes and not as a last step to survive a problematic investigational drug candidate.