Cadherin switches during epithelial-mesenchymal transition: CDH4/RCAD downregulation reduces bladder cancer progression.

Cláudia Martins-Lima Vera Miranda-Gonçalves João Lobo Vera Constâncio Pedro Leite-Silva Catarina Guimarães-Teixeira Sara Monteiro-Reis José Pedro SequeiraMariana CantanteCéline S Gonçalves Bruno M Costa Rui M Henrique Carmen Jerónimo

Published in: Cellular oncology (Dordrecht) (2022)

Our data indicate that E-, P- and R-cadherin switches occur in BlCa, being associated with tumor progression. Promoter methylation is not the likely mechanism underlying cadherin expression deregulation. Our findings suggest an oncogenic role of RCAD in BlCa progression.

Keyphrases

epithelial mesenchymal transition
poor prognosis
cell adhesion
cell migration
dna methylation
transcription factor
signaling pathway
transforming growth factor
cell proliferation
electronic health record
genome wide
long non coding rna
big data
binding protein
machine learning