Differential Gain-of-Function Activity of Three p53 Hotspot Mutants In Vivo.
Shunbin XiongDhruv ChachadYun ZhangJovanka Gencel-AugustoMario SiritoVinod PantPeirong YangChang SunGilda P ChauYuan QiXiaoping SuElizabeth M WhitleyAdel K El-NaggarGuillermina LozanoPublished in: Cancer research (2022)
p53 hotspot mutants inhibit wild-type p53 similarly but differ in their GOF activities, with stronger tumor-promoting activity in contact mutants and distinct protein partners of each mutant driving tumorigenesis and metastasis.