Curcumin Inhibits the Growth of Hepatocellular Carcinoma via the MARCH1-mediated Modulation of JAK2/STAT3 Signaling.

Jiaqi SuXianbing LiuXiaoyue ZhaoHongjie MaYuzhu JiangXu WangPeiyuan WangMingdong ZhaoXuemei Hu

Published in: Recent patents on anti-cancer drug discovery (2024)

Our results demonstrated that curcumin may inhibit the activation of JAK2/STAT3 signaling pathway by downregulating MARCH1 expression, resulting in the growth suppression of HCC. MARCH1 may be a novel target of curcumin in HCC treatment.

Keyphrases

signaling pathway
poor prognosis

epithelial mesenchymal transition
binding protein

combination therapy

replacement therapy