Duodenal alpha-Synuclein Pathology and Enteric Gliosis in Advanced Parkinson's Disease.

Aron EmmiMichele SandreFrancesco Paolo RussoGiulia TombesiFederica GarrìMarta CampagnoloMiryam CarecchioRoberta BiundoGaya SpolveratoVeronica MacchiEdoardo SavarinoFabio FarinatiPiero ParchiAndrea PorzionatoLuigi BubaccoRaffaele De CaroGabor G KovacsAngelo Antonini

Published in: Movement disorders : official journal of the Movement Disorder Society (2023)

We found evidence of synuclein pathology and gliosis in the duodenum of patients with PD, including early de novo cases. Future studies are required to evaluate how early in the disease process duodenal pathology occurs and its possible contribution to levodopa effect in chronic patients. © 2023 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.

Keyphrases

end stage renal disease
ejection fraction
peritoneal dialysis
prognostic factors
randomized controlled trial
parkinson disease
deep brain stimulation
case control
patient reported