Unraveling NEAT1's complex role in lung cancer biology: a comprehensive review.
Md Sadique HussainObaid AfzalGaurav GuptaAhsas GoyalWaleed Hassan AlmalkiImran KazmiSami I AlzareaAbdulmalik Saleh Alfawaz AltamimiNeelam KukretiAmlan ChakrabortySachin Kumar SinghKamal DuaPublished in: EXCLI journal (2024)
This review delves into the pivotal role of the long non-coding RNA NEAT1 in cancer biology, particularly in lung cancer (LC). It emphasizes NEAT1's unique subcellular localization and active involvement in gene regulation and chromatin remodeling. The review highlights NEAT1's impact on LC development and progression, including cell processes such as proliferation, migration, invasion, and resistance to therapy, positioning it as a potential diagnostic marker and therapeutic target. The complex web of NEAT1's regulatory interactions with proteins and microRNAs is explored, alongside challenges in targeting it therapeutically. The review concludes optimistically, suggesting future avenues for research and personalized LC therapies, shedding light on NEAT1's crucial role in LC. See also the Graphical abstract(Fig. 1).
Keyphrases
- long non coding rna
- simultaneous determination
- poor prognosis
- transcription factor
- gene expression
- mass spectrometry
- liquid chromatography
- signaling pathway
- single cell
- cell therapy
- dna damage
- stem cells
- high resolution
- squamous cell carcinoma
- risk assessment
- genome wide
- mesenchymal stem cells
- bone marrow
- cancer therapy
- climate change