Exposure to arsenic at different life-stages and DNA methylation meta-analysis in buccal cells and leukocytes.
Anne K BozackPhilippe BoileauLinqing WeiAlan E HubbardFenna C M SilléCatterina FerreccioJohanna AcevedoLifang HouVesna IlievskiCraig M SteinmausMartyn T SmithAna Navas-AcienMary V GambleAndres CardenasPublished in: Environmental health : a global access science source (2021)
Using a two-step process of (1) harmonized data processing and analysis and (2) meta-analysis, we leverage four DNAm datasets from two continents of individuals exposed to high levels of As prenatally and during adulthood to identify DMPs and DVPs associated with arsenic exposure. Our approach suggests that standardizing analytical pipelines can aid in identifying biological meaningful signals.
Keyphrases
- dna methylation
- systematic review
- drinking water
- induced apoptosis
- heavy metals
- cell cycle arrest
- gene expression
- meta analyses
- genome wide
- depressive symptoms
- electronic health record
- peripheral blood
- big data
- randomized controlled trial
- liquid chromatography
- oxidative stress
- copy number
- data analysis
- mass spectrometry
- cell proliferation