A multicomponent tetrazolo indole synthesis.
Xiaofang LeiPanagiota LampiriPravin PatilGiasemi K AngeliConstantinos G NeochoritisAlexander S S DömlingPublished in: Chemical communications (Cambridge, England) (2021)
The ubiquitous presence of the indole fragment in natural products and drugs asks for ever novel syntheses. We report an unprecedented mild, two-step synthesis of 2-tetrazolo substituted indoles based on the Ugi-tetrazole reaction combined with an acidic ring closure. A gram-scale synthesis, a bioactive compound and further transformations were performed.