Evaluation of Serum Mucorales Polymerase Chain Reaction (PCR) for the Diagnosis of Mucormycoses: The MODIMUCOR Prospective Trial.
Laurence MillonDenis CaillotAna BerceanuStéphane BretagneFanny LanternierFlorent MorioValérie Letscher-BruFrédéric DalleBlandine DenisAlexandre AlanioDavid BoutoilleMarie-Elisabeth BougnouxFrançoise BotterelTaieb ChouakiAmandine CharbonnierFlorence AderDamien DupontAnne Pauline BellangerSteffi RocchiEmeline SchererHoussein Gbaguidi-HaoreRaoul HerbrechtPublished in: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America (2022)
Our study argues for the inclusion of qPCR for the detection of circulating Mucorales DNA for mucormycosis diagnosis and follow-up after treatment initiation. Positive results should be added to the criteria for the consensual definitions from the European Organization for the Research and Treatment of Cancer/Mycoses Study Group Education and Research Consortium (EORTC/MSGERC), as already done for Aspergillus PCR.