Insulin resistance induced by growth hormone is linked to lipolysis and associated with suppressed pyruvate dehydrogenase activity in skeletal muscle: a 2 × 2 factorial, randomised, crossover study in human individuals.

Astrid Johannesson Hjelholt Evelina Charidemou Julian Leether Griffin Steen Bønlykke Pedersen Anders Gudiksen Henriette Pilegaard Niels Jessen Niels Møller Jens Otto Lunde Jørgensen

Published in: Diabetologia (2020)

ClinicalTrials.gov NCT02782208 FUNDING: The work was supported by the Grant for Growth Innovation (GGI), which was funded by Merck KGaA, Darmstadt, Germany. Graphical abstract.

Keyphrases

insulin resistance
growth hormone
skeletal muscle
adipose tissue
endothelial cells

clinical trial
high fat diet
metabolic syndrome
open label

polycystic ovary syndrome
induced pluripotent stem cells
type diabetes
high fat diet induced

study protocol
double blind
pluripotent stem cells
placebo controlled