Development and validation of a methotrexate adherence assay.
James BluettIsabel Riba-GarciaSuzanne M M VerstappenThierry WendlingKayode OgungbenroRichard D UnwinAnne BartonPublished in: Annals of the rheumatic diseases (2019)
Non-adherence to MTX is common and can have a significant effect on disease activity. HPLC-SRM-MS plasma analysis accurately detects MTX adherence. The validated objective test could easily be used in clinic to identify patients requiring adherence support.
Keyphrases
- disease activity
- rheumatoid arthritis
- systemic lupus erythematosus
- ms ms
- mass spectrometry
- ejection fraction
- ankylosing spondylitis
- rheumatoid arthritis patients
- primary care
- multiple sclerosis
- type diabetes
- prognostic factors
- juvenile idiopathic arthritis
- simultaneous determination
- high dose
- low dose
- high resolution
- high performance liquid chromatography
- single cell
- liquid chromatography
- solid phase extraction