Impact of the Multiple Sclerosis-Associated Genetic Variant CD226 Gly307Ser on Human CD8 T-Cell Functions.

Elena MorandiVéronique AdoueIsabelle BernardEkaterina FriebelNicolas NunezYann Aubert Frederick MassonAnne S DejeanBurkhard BecherAnne AstierLudovic Martinet Abdelhadi Saoudi

Published in: Neurology(R) neuroimmunology & neuroinflammation (2024)

Our data suggest that the CD226-307Ser risk variant imposes immune dysregulation by increasing the pathways related to IFNγ signaling in CD8 T cells, thereby contributing to the risk of developing chronic inflammation.

Keyphrases

multiple sclerosis
endothelial cells
oxidative stress
nk cells
immune response
electronic health record
dendritic cells
induced pluripotent stem cells
genome wide
big data
white matter
gene expression
copy number