Genosets for APOE and CYP7A1-rs3808607 variants do not predict low-density lipoprotein cholesterol lowering upon intervention with plant sterols in a randomized, double-blind, placebo-controlled trial.

APOE and CYP7A1 genotypes did not influence the efficacy of LDL-C reductions upon dietary intervention with PS. Findings of previous post-hoc analyses could not be validated in a trial using a priori genotype-based recruitment. Obtaining adequate numbers of participants is challenging in trials using genoset-based recruitment, even for common variants.Trial Registration: Clinical Trials #NCT02765516 https://clinicaltrials.gov/ct2/show/NCT02765516.