Activated factor X stimulates atrial endothelial cells and tissues to promote remodeling responses through AT1R/NADPH oxidases/SGLT1/2.
Walaa FakihAli MrouehDal-Seong GongShinnosuke KikuchiMichael Paul PieperMichel KindoJean-Philippe MazzucottelliArnaud MommerotMohamad KansoPatrick OhlmannOlivier MorelValérie Schini-KerthLaurence JeselPublished in: Cardiovascular research (2024)
FXa promotes oxidative stress triggering premature endothelial senescence and dysfunction associated with pro-thrombotic, pro-remodeling and pro-fibrotic responses in AECs and in human RAA involving the AT1R/NADPH oxidases/SGLT1/2 pro-oxidant pathway. Targeting this pathway may be of interest to prevent atrial remodeling and the progression of atrial fibrillation substrate.
Keyphrases
- endothelial cells
- atrial fibrillation
- anti inflammatory
- oxidative stress
- left atrial
- catheter ablation
- high glucose
- dna damage
- heart failure
- reactive oxygen species
- oral anticoagulants
- gene expression
- left atrial appendage
- percutaneous coronary intervention
- endoplasmic reticulum stress
- stress induced
- acute coronary syndrome
- diabetic rats
- pluripotent stem cells