A novel RHCE*02 allele, containing the single-nucleotide change c.460A>G, encodes weakened expression of C and e antigens.

Åsa HellbergEmma PesjakJessica KarlssonJill R Storry

Published in: Transfusion (2016)

We report a novel RHCE*02 allele in a Swedish blood donor that is characterized by the change c.460A>G (Arg154Gly). The blood donor's red blood cells showed variable reactivity with different monoclonal anti-C and anti-e and antigen strength was markedly weakened. We believe that these changes represent both a quantitative and qualitative alteration of the antigens encoded by this allele.

Keyphrases

red blood cell
dendritic cells
poor prognosis
systematic review
high resolution
binding protein
mass spectrometry