Mapping vitamin B6 metabolism by hydrazoCEST magnetic resonance imaging.

Emilie Marie Sophie Patit-Tha BrunNicholas David CalvertMojmír SuchýAlexia KirbyGerd MelkusRuslan GaripovChristina Lynn Addison Adam J Shuhendler

Published in: Chemical communications (Cambridge, England) (2021)

A new CEST-MRI contrast agent, 2-HYNIC, capable of sensing aromatic aldehydes is reported. Pyridoxal 5'-phosphate, a key Vitamin B6 metabolite necessary for >140 biotransformations was mapped by CEST-MRI in vitro and in vivo in lung cancer. 2-HYNIC provided access to this key biomarker associated with a variety of human diseases.

Keyphrases

contrast enhanced
magnetic resonance imaging
diffusion weighted imaging
magnetic resonance
computed tomography
endothelial cells
high resolution
induced pluripotent stem cells
amino acid
pluripotent stem cells
mass spectrometry