GJB5 association with BRAF mutation and survival in cutaneous malignant melanoma.

Maria ScatoliniA PatelE GrossoMaurizia Mello-Grand Paola OstanoR CoppoM VitielloT VenesioA ZaccagnaA PisacaneI SarottoD TavernaL PolisenoDaniele Bergamaschi Giovanna Chiorino

Published in: The British journal of dermatology (2021)

We identified a significant association between metastases/BRAF mutation and low GJB5 expression in melanoma. Our results identify a novel mechanism of gap-junctional protein regulation, suggesting a prognostic role for GJB5 in cutaneous melanoma.

Keyphrases

hearing loss
poor prognosis
metastatic colorectal cancer
skin cancer
binding protein
wild type
basal cell carcinoma