The protective effect of N-acetylcysteine against MK-801-induced neurodegeneration in mice.
Murat Sırrı AkosmanRuhi TurkmenHasan Hüseyin DemirelPublished in: Molecular biology reports (2023)
In the mice given NAC as a protective agent, it was observed that behavioral problems improved, antioxidant levels increased, and nuclear shrinkage, glial cell infiltration, vacuolization in neurons, and white matter degeneration were prevented. Moreover, MBP expression increased, and the number of TUNEL-positive cells significantly decreased. As a result, it was observed that NAC may have a protective effect against brain degeneration.
Keyphrases
- white matter
- transcription factor
- high fat diet induced
- induced apoptosis
- poor prognosis
- mental health
- oxidative stress
- single cell
- multiple sclerosis
- cell cycle arrest
- high glucose
- diabetic rats
- spinal cord
- resting state
- cell therapy
- neuropathic pain
- type diabetes
- stem cells
- endoplasmic reticulum stress
- metabolic syndrome
- genome wide analysis
- functional connectivity
- cell death
- anti inflammatory
- long non coding rna
- endothelial cells
- adipose tissue
- cell proliferation
- brain injury