Transcriptomic analysis and validation reveal the pathogenesis and a novel biomarker of acute exacerbation of chronic obstructive pulmonary disease.
Huijie WangYonghong ZhongNa LiMin YuLin ZhuLina WangFei ChenYaping XuJian LiuHuaqiong HuangPublished in: Respiratory research (2022)
WNT/β-catenin signaling pathway is down-regulated in AECOPD patients and in animal models of COPD. Increased expression of phosphorylated β-catenin in the blood might be a potential biomarker of AECOPD. Activation of WNT/β-catenin pathway may also represent a therapeutic target for AECOPD.
Keyphrases
- chronic obstructive pulmonary disease
- cell proliferation
- end stage renal disease
- stem cells
- ejection fraction
- newly diagnosed
- poor prognosis
- chronic kidney disease
- liver failure
- respiratory failure
- peritoneal dialysis
- epithelial mesenchymal transition
- genome wide
- transcription factor
- gene expression
- dna methylation
- cystic fibrosis
- intensive care unit
- hepatitis b virus
- signaling pathway
- extracorporeal membrane oxygenation
- acute respiratory distress syndrome