Effect of Hyperthermic Intraperitoneal Chemotherapy on Cytoreductive Surgery in Gastric Cancer With Synchronous Peritoneal Metastases: The Phase III GASTRIPEC-I Trial.

Beate RauHauke LangAlfred KoenigsrainerInes Gockel Horst-Guenter Rau Hendrik SeeligerChristian LerchenmuellerDaniel ReimRoger WahbaMartin AngeleSteffen HeegTobias KeckArved WeimannStefan ToppPompiliu PisoAndreas Brandl Silke SchuelePeter JoJohann PratschkeSandra WegelAlexander RehdersNicolas MoosmannJochen Gaedcke Volker Heinemann Evelyn TripsMarkus LoefflerPeter Michael SchlagPeter C Thuss-Patience

Published in: Journal of clinical oncology : official journal of the American Society of Clinical Oncology (2023)

This study showed no OS difference between CRS + H and CRS-A. PFS and MFS were significantly better in the CRS + H group, which needs further exploration. HIPEC did not increase AEs.

Keyphrases

phase iii
open label
clinical trial
phase ii
minimally invasive
double blind
study protocol
squamous cell carcinoma
randomized controlled trial
locally advanced
coronary artery disease
metastatic renal cell carcinoma