Targeting the epitope spreader Pep19 by naïve human CD45RA+ regulatory T cells dictates a distinct suppressive T cell fate in a novel form of immunotherapy.

Hyun-Joo Kim Gil Sun Cha Ji-Young Joo Ju-Youn Lee Sung-Jo Kim Jeongae Lee So Youn Park Jeom-Il Choi

Published in: Journal of periodontal & implant science (2017)

We propose human naïve CD4+CD25+CD45RA+ Tregs and the epitope spreader Pep19 as cellular and molecular targets for a novel antigen-specific Treg-based vaccination against collagen-induced arthritis.

Keyphrases

regulatory t cells
endothelial cells
rheumatoid arthritis
cell fate
high glucose
induced pluripotent stem cells
dendritic cells
pluripotent stem cells
disease activity
ankylosing spondylitis
monoclonal antibody
cancer therapy
immune response
oxidative stress
systemic lupus erythematosus