Genetic and lifestyle risk factors for MRI-defined brain infarcts in a population-based setting.
Ganesh ChauhanHieab H H AdamsClaudia L SatizabalJoshua C BisAlexander TeumerMuralidharan SargurupremrajEdith HoferStella TrompetSaima HilalAlbert Vernon SmithXueqiu JianRainer MalikMatthew TraylorSara L PulitPhilippe AmouyelBernard MazoyerYi-Cheng ZhuSara KaffashianSabrina SchillingGary W BeechamThomas J MontineGerard D SchellenbergOlafur KjartanssonVilmundur GuðnasonDavid S KnopmanMichael E GriswoldB Gwen WindhamRebecca F GottesmanThomas H MosleyReinhold SchmidtYasaman SabaHelena SchmidtFumihiko TakeuchiShuhei YamaguchiToru NabikaNorihiro KatoKumar B RajanNeelum T AggarwalPhilip L De JagerDenis A EvansBruce M PsatyJerome I RotterKenneth RiceOscar L LopezJiemin LiaoChristopher ChenChing-Yu ChengTien Y WongMohammad K IkramSven J van der LeeNajaf AminVincent ChourakiAnita L DeStefanoHugo J AparicioJose R RomeroPauline MaillardCharles DeCarliJoanna M WardlawMaria Del C Valdés HernándezMichelle LucianoDavid LiewaldIan J DearyJohn M StarrMark E BastinSusana Muñoz ManiegaP Eline SlagboomMarian BeekmanJoris DeelenHae-Won UhRobin LemmensHenry BrodatyMargaret J WrightDavid AmesGiorgio B BoncoraglioJemma C HopewellAshley H BeechamSusan H BlantonClinton B WrightRalph L SaccoWei WenAnbupalam ThalamuthuNicola J ArmstrongElizabeth ChongPeter R SchofieldJohn B J KwokJeroen van der GrondDavid J StottIan FordJ Wouter JukemaMeike W VernooijAlbert HofmanAndré G UitterlindenAad van der LugtKatharina WittfeldHans Jörgen GrabeNorbert HostenBettina von SarnowskiUwe VölkerChristopher LeviJordi Jimenez-CondePankaj SharmaCathie L M SudlowJonathan RosandDaniel WooJohn W ColeJames F MeschiaAgnieszka SlowikVincent N ThijsArne LindgrenOlle MelanderRaji P GrewalTatjana RundekKathy RexrodePeter M RothwellDonna K ArnettChristina JernJulie A JohnsonOscar R BenaventeSylvia Wasssertheil-SmollerJin-Moo LeeQuenna WongBraxton D MitchellStephen S RichPatrick F McArdleMirjam I GeerlingsYolanda van der GraafPaul I W de BakkerFolkert W. AsselbergsVelandai SrikanthRussell ThomsonRebekah McWhirterChris MoranMichele CallisayaThanh PhanLoes C A Rutten-JacobsSteve BevanChristophe TzourioKaren A MatherPerminder S SachdevCornelia M van DuijnBradford B WorrallMartin DichgansSteven J KittnerHugh S MarkusMohammad A IkramMyriam FornageLenore J LaunerSudha SeshadriW T LongstrethStéphanie Debettenull nullPublished in: Neurology (2019)
In this multiethnic GWAS meta-analysis, including over 20,000 population-based participants, we identified genetic risk loci for BI requiring validation once additional large datasets become available. High BP, including genetically determined, was the most significant modifiable, causal risk factor for BI.
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