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Evaluation of approaches for multiple imputation of three-level data.

Rushani WijesuriyaMargarita Moreno-BetancurJohn B CarlinKatherine J Lee
Published in: BMC medical research methodology (2020)
Researchers may use extensions to the single- and two-level approaches, or the three-level approaches, to adequately handle incomplete three-level data. The two-level MI approaches with dummy indicator extension or the MI approaches based on three-level models will be required in certain circumstances such as when there are longitudinal data measured at irregular time intervals. However, the single- and two-level approaches with the DI extension should be used with caution as the DI approach has been shown to produce biased parameter estimates in certain scenarios.
Keyphrases
  • electronic health record
  • big data
  • staphylococcus aureus
  • mass spectrometry
  • cross sectional
  • artificial intelligence
  • molecularly imprinted