Identification of scavenger receptor B1 as the airway microfold cell receptor for Mycobacterium tuberculosis.
Haaris S KhanVidhya R NairCody R RuhlSamuel Alvarez-ArguedasJorge L Galvan RendizLuis H FrancoLinzhang HuangPhilip W ShaulJiwoong KimYang XieRon B MitchellMichael U ShilohPublished in: eLife (2020)
Mycobacterium tuberculosis (Mtb) can enter the body through multiple routes, including via specialized transcytotic cells called microfold cells (M cell). However, the mechanistic basis for M cell entry remains undefined. Here, we show that M cell transcytosis depends on the Mtb Type VII secretion machine and its major virulence factor EsxA. We identify scavenger receptor B1 (SR-B1) as an EsxA receptor on airway M cells. SR-B1 is required for Mtb binding to and translocation across M cells in mouse and human tissue. Together, our data demonstrate a previously undescribed role for Mtb EsxA in mucosal invasion and identify SR-B1 as the airway M cell receptor for Mtb.
Keyphrases
- mycobacterium tuberculosis
- induced apoptosis
- pulmonary tuberculosis
- single cell
- cell cycle arrest
- cell therapy
- signaling pathway
- endoplasmic reticulum stress
- deep learning
- oxidative stress
- pseudomonas aeruginosa
- bone marrow
- palliative care
- blood brain barrier
- staphylococcus aureus
- big data
- machine learning
- pluripotent stem cells
- bioinformatics analysis