Expeditious Access to the B 3 NO 2 Heterocycle Enabling Modular Derivatization.
Ryosuke TsutsumiNobuaki KashiwagiNaoya KumagaiPublished in: The Journal of organic chemistry (2023)
DATB (1,3-dioxa-5-aza-2,4,6-triborinane) is a unique six-membered heterocycle exhibiting proficient catalytic activity in direct dehydrative amidation. Reported herein is an improved synthetic protocol for DATB derivatives featuring a concise two-step chromatography-free process. Suzuki-Miyaura coupling assembled 2,6-dibromoaniline derivatives and 1,2-phenylenediboronic acid to afford dimeric B -spiroborate salts. Acidic untying of the spiroborates gave rise to the DATB ring system with various substituents.
Keyphrases
- high performance liquid chromatography
- tandem mass spectrometry
- liquid chromatography
- ionic liquid
- mass spectrometry
- ms ms
- structure activity relationship
- randomized controlled trial
- room temperature
- ultra high performance liquid chromatography
- liquid chromatography tandem mass spectrometry
- simultaneous determination
- high speed
- gas chromatography mass spectrometry
- high resolution