Expression of circadian regulatory genes is dysregulated by increased cytokine production in mice subjected to concomitant intestinal injury and parenteral nutrition.

Colin T ShearnAimee L AndersonMichael W DevereauxKarim C El KasmiDavid J OrlickyRonald J Sokol

Published in: PloS one (2023)

Altered expression of CR-dependent regulatory genes during PNAC accompanies cholestasis and is, in part, due to increased cytokine (IL-1β and TNFα) production. Evaluation of the effects of modulating CR in PNAC thus deserves further investigation.

Keyphrases

poor prognosis
genome wide
transcription factor
rheumatoid arthritis
binding protein
bioinformatics analysis
long non coding rna
high fat diet induced
gene expression
metabolic syndrome
genome wide analysis
adipose tissue
skeletal muscle