Complement component C1q initiates extrinsic coagulation via the receptor for the globular head of C1q in adventitial fibroblasts and vascular smooth muscle cells.

Christopher T FredaWei YinBerhane GhebrehiwetDavid A Rubenstein

Published in: Immunity, inflammation and disease (2023)

This indicates that gC1qR association with C1q induces TF expression and may initiate extrinsic coagulation. Overall, this data illustrates a role for C1q in the activation of extrinsic coagulation and that gC1qR activity may link inflammation and thrombosis.

Keyphrases

vascular smooth muscle cells
angiotensin ii
poor prognosis
oxidative stress
pulmonary embolism
gas chromatography
binding protein
electronic health record
big data
extracellular matrix
mass spectrometry