Systematic review of pharmacological management in Creutzfeldt-Jakob disease: no options so far?
Luiz Henrique Lélis MirandaAndré Felipe Pastick de Holanda OliveiraDavi Mariano de CarvalhoGustavo Marques Figueredo SouzaJoão Guilherme Monteiro MagalhãesJoselmo Alberto Cabral JúniorPedro Thadeu Mertens Brainer de Queiroz LimaRenato Melo Aguiar JúniorSérgio Pereira Lins FilhoHugo Moura de Albuquerque MeloPublished in: Arquivos de neuro-psiquiatria (2022)
None of the drugs evaluated proved significantly effective in increasing survival in patients with CJD. Flupirtine appears to have a beneficial effect in reducing cognitive deterioration in patients with CJD. However, additional studies are needed to establish better evidence and therapeutic options for the management of patients with CJD.