Login / Signup

MAL expression downregulation through suppressive H3K27me3 marks at the promoter in HPV16-related cervical cancers is prognostically relevant and manifested by the interplay of novel MAL antisense long noncoding RNA AC103563.8, E7 oncoprotein and EZH2.

Abarna SinhaAbhisikta GhoshArnab GhoshSonia MathaiJaydip BhaumikAsima MukhopadhyayArindam MaitraNidhan K BiswasSharmila Sengupta
Published in: Clinical epigenetics (2024)
AC103563.8-E7-EZH2 axis, therefore, appears to crucially regulate the expression of MAL, through chromatin inactivation in HPV16-CaCx pathogenesis, warranting therapeutic strategy development.
Keyphrases