P16 Expression in Extramammary Paget's Disease of the Vulva and Scrotum Is Not Human Papillomavirus Related.

Khaleel I Al-ObaidyChia-Sui KaoMuhammad T Idrees

Published in: International journal of surgical pathology (2018)

Both vulvar and scrotal EMPD can express p16 by IHC, more commonly vulvar than scrotal; however, no HPV was detected either by IHC or in situ hybridization. EMPD of vulva and scrotum does not appear to be related to HPV, and p16 expression may be regulated through a different mechanism.

Keyphrases

poor prognosis
high grade
sentinel lymph node
binding protein
transcription factor
long non coding rna
radiation therapy
early stage
neoadjuvant chemotherapy
drug induced
locally advanced