A facile approach to prepare silica hybrid, spin-crossover water-soluble nanoparticles as potential candidates for thermally responsive MRI agents.
Patroula GkolfiDimitra TsivakaIoannis TsougosKaterina VassiouOndřéj MalinaMichaela PolaskovaChristina D PolyzouChristos T ChasapisVassilis TangoulisPublished in: Dalton transactions (Cambridge, England : 2003) (2021)
A reverse micelle method was used for the synthesis of water-soluble silica hybrid, spin-crossover (SCO) nanoparticles (NPs). MRI experiments provided temperature dependent T2 values, indicating their potential use as smart MRI agents, while lyophilization of NP dispersions in water yielded powders with a preserved but modified thermal hysteretic magnetic profile.
Keyphrases
- water soluble
- contrast enhanced
- magnetic resonance imaging
- diffusion weighted imaging
- open label
- density functional theory
- room temperature
- double blind
- magnetic resonance
- clinical trial
- human health
- randomized controlled trial
- computed tomography
- placebo controlled
- risk assessment
- molecularly imprinted
- transition metal
- quantum dots