Electrospun, synthetic bone void filler promotes human MSC function and BMP-2 mediated spinal fusion.

Juliane D GlaeserKhosrowdad SalehiLinda Ea KanimDerek G JuJae Hyuk YangPhillip H BehrensSamuel A EberleinMelodie F MetzgerYasaman ArabiTina StefanovicDmitriy SheynHyun W Bae

Published in: Journal of biomaterials applications (2020)

Reb possesses a high protein binding affinity and promotes hMSC function. Combination with BMA and minimal dose BMP-2 allowed for 100% bone fusion in vivo. This data suggests that a minimally effective dose of BMP-2 can be used when combined with Reb.

Keyphrases

bone regeneration
mesenchymal stem cells
bone mineral density
endothelial cells
soft tissue
spinal cord
bone loss
hyaluronic acid
machine learning
small molecule
pluripotent stem cells
protein protein
bone marrow
body composition