Comparative analysis of the DNA methylation landscape in CD4, CD8, and B memory lineages.

Ze Zhang Rondi A Butler Devin C KoestlerShelby Bell-GlennGayathri WarrierAnnette M Molinaro Brock C Christensen John K Wiencke Karl T Kelsey Lucas A Salas

Published in: Clinical epigenetics (2022)

Our data suggest that epigenetic alterations are widespread and essential in generating human lymphocyte memory. Unique profiles are involved in methylation changes that accompany memory genesis in the three subtypes of lymphocytes.

Keyphrases

dna methylation
working memory
genome wide
gene expression
endothelial cells
peripheral blood
electronic health record
induced pluripotent stem cells
big data
machine learning
artificial intelligence