Fibrosis and Immune Cell Infiltration Are Separate Events Regulated by Cell-Specific Receptor Notch3 Expression.

Sabine BrandtTobias-Malte BallhauseAnja BernhardtAnnika BeckerDelia SalaruHien Minh Le-DeffgeAlexander FehrYan FuLars PhilipsenSonja DjudjajAndreas J MüllerRafael KramannMahmoud IbrahimRobert GeffersChris SiebelBerend IsermannFlorian H HeidelJonathan A LindquistPeter R Mertens

Published in: Journal of the American Society of Nephrology : JASN (2020)

Cell-specific receptor Notch3 signaling independently orchestrates leukocyte infiltration and organ fibrosis. Interference with Notch3 signaling may present a novel therapeutic approach in inflammatory as well as fibrotic diseases.

Keyphrases

single cell
cell therapy
poor prognosis
binding protein
oxidative stress
systemic sclerosis
liver fibrosis