A prolactin-dependent sexually dimorphic mechanism of migraine chronification.

Daigo IkegamiEdita NavratilovaXu YueAubin MoutalCaroline M KopruszinskiRajesh KhannaAmol PatwardhanDavid W DodickFrank Porreca

Published in: Cephalalgia : an international journal of headache (2021)

We identified a sexually dimorphic mechanism of migraine chronification that involves down-regulation of PRLR-L and increased signaling of circulating prolactin at PRLR-S. These studies reveal a previously unrecognized neuroendocrine mechanism linking the hypothalamus to nociceptor sensitization that increases the risk of migraine pain in females and suggest opportunities for novel sex-specific therapies including gene editing through nasal delivery of CRISPR/Cas9 constructs.

Keyphrases

crispr cas
genome editing
chronic pain
pain management
genome wide
neuropathic pain
gene expression
growth hormone
postoperative pain