The effects of daily dose and treatment duration of metformin on the prevalence of vitamin B12 deficiency and peripheral neuropathy in Chinese patients with type 2 diabetes mellitus: A multicenter cross-sectional study.
Leili GaoXingwu RanXuejun LiuXingping ShenShuchun ChenFuqiang LiuDong ZhaoYan BiQing SuYao LuMinxiang LeiYanfang WangXiantong ZouPublished in: Journal of diabetes (2023)
High daily dosage (≥1500 mg/day) played an important role in metformin-associated vitamin B12 deficiency while not contributing to the risk of PN.