NADPH Oxidase 2 Has a Crucial Role in Cell Cycle Progression of Esophageal Squamous Cell Carcinoma.

Hiroki ShimizuKeita KatsuraharaHiroyuki InoueAtsushi ShiozakiToshiyuki KosugaMichihiro KudouTomohiro AritaHirotaka KonishiShuhei KomatsuHitoshi FujiwaraYukiko MorinagaEiichi KonishiEigo Otsuji

Published in: Annals of surgical oncology (2022)

NOX2 expression in ESCC cells affects tumorigenesis, especially cell cycle progression via the BTG2-related signaling pathway, as well as the prognosis of patients with ESCC. NOX2 may be a novel biomarker and therapeutic target for ESCC.

Keyphrases

cell cycle
induced apoptosis
signaling pathway
cell proliferation
cell cycle arrest
pi k akt
poor prognosis
reactive oxygen species
endoplasmic reticulum stress
epithelial mesenchymal transition
oxidative stress
binding protein