Skin 11β-hydroxysteroid dehydrogenase type 1 enzyme expression regulates burn wound healing and can be targeted to modify scar characteristics.
Kevin H-Y TsaiHuaikai ShiRoxanne J ParungaoSina NaficyXiaotong DingXiaofeng DingJonathan J HewXiaosuo WangWojciech ChrzanowskiGareth G LaveryZhe LiAndrea C Issler-FisherJun ChenQian TanPeter K MaitzMark S CooperYiwei WangPublished in: Burns & trauma (2023)
Skin 11β-HSD1 expression is a key regulator of wound healing and scarring after burn injury. Application of an inactive glucocorticoid capable of activation by local 11β-HSD1 in skin slows the initial rate of wound closure but significantlyimproves scar characteristics post burn injury.