Night Shift Work, Genetic Risk, and Type 2 Diabetes in the UK Biobank.

Céline VetterHassan S DashtiJacqueline M LaneSimon George AndersonEva S SchernhammerMartin K RutterRicha SaxenaFrank A J L Scheer

Published in: Diabetes care (2018)

Our findings show that night shift work, especially rotating shift work including night shifts, is associated with higher type 2 diabetes odds and that the number of night shifts worked per month appears most relevant for type 2 diabetes odds. Also, shift work exposure does not modify genetic risk for type 2 diabetes, a novel finding that warrants replication.

Keyphrases

skeletal muscle
type diabetes
insulin resistance
glycemic control
cardiovascular disease
sleep quality
genome wide
cross sectional
copy number
gene expression
metabolic syndrome
depressive symptoms
weight loss