CX-5461 Inhibits Pancreatic Ductal Adenocarcinoma Cell Growth, Migration and Induces DNA Damage.

Btissame El HassouniGiulia MantiniBenoît ImmordinoGodefridus J PetersElisa Giovannetti

Published in: Molecules (Basel, Switzerland) (2019)

This study demonstrated that CX-5461 is active against pancreatic cancer cells and modulation of EMT factors, as well as increased expression of phospho-H2A.X, support further pre-/clinical investigations, including the analyses of these markers.

Keyphrases

dna damage
poor prognosis
oxidative stress
epithelial mesenchymal transition
dna repair
binding protein
long non coding rna