CD200 promotes immunosuppression in the pancreatic tumor microenvironment.

Fouad ChoueiryMolly TorokReena ShakyaKriti AgrawalAnna DeemsBrooke BennerAlice HintonJami ShafferBradley W BlaserAnne M NoonanTerence M WilliamsMary DillhoffDarwin L ConwellPhil A HartZobeida Cruz-MonserrateXue-Feng BaiWilliam E CarsonThomas A Mace

Published in: Journal for immunotherapy of cancer (2020)

These results indicate that CD200 expression in the PDAC microenvironment may regulate MDSC expansion and that targeting CD200 may enhance activity of checkpoint immunotherapy.

Keyphrases

nk cells
poor prognosis
stem cells
oxidative stress
binding protein