iNOS Deletion in Alveolar Epithelium Cannot Reverse the Elastase-Induced Emphysema in Mice.
Marija GredicVinita SharmaStefan HadzicCheng-Yu WuOleg PakBaktybek KojonazarovJulia DuerrMarcus Alexander MallAndreas GuentherRalph T SchermulyFriedrich GrimmingerHorst-Walter BirkSimone KrautNatascha SommerNorbert WeissmannPublished in: Cells (2022)
taken together, our data demonstrate that iNOS deletion in AECII is not sufficient for the regeneration of emphysematous murine lungs, and suggest that iNOS expression in pulmonary vascular or stromal cells might be critically important in this regard.
Keyphrases
- nitric oxide synthase
- poor prognosis
- stem cells
- nitric oxide
- pulmonary hypertension
- high glucose
- chronic obstructive pulmonary disease
- diabetic rats
- electronic health record
- high fat diet induced
- idiopathic pulmonary fibrosis
- lung function
- drug induced
- type diabetes
- oxidative stress
- metabolic syndrome
- adipose tissue
- cystic fibrosis
- artificial intelligence
- wild type