Prognostic impact of CD34 and SMA in cancer-associated fibroblasts in stage I-III NSCLC.

Arik Bernard SchulzeLars Henning SchmidtBirthe HeitkötterSebastian HussMichael MohrAlessandro MarraLudger HillejanDennis GörlichPeter J BarthJan RehkämperGeorg Evers

Published in: Thoracic cancer (2019)

Expression of CD34 on cancer associated fibroblasts (CAFs) is an independent prognostic factor in stage I-III NSCLC. SMA+ cancer associated fibroblasts are associated with higher tumor stages in NSCLC and might contribute to tumor progression in NSCLC.

Keyphrases

small cell lung cancer
advanced non small cell lung cancer
prognostic factors
poor prognosis
extracellular matrix
brain metastases
epidermal growth factor receptor
nk cells