Helicobacter pylori induces gastric cancer via down-regulating miR-375 to inhibit dendritic cell maturation.

Zhenxing ZhangSimiao ChenMenghui FanGuojing RuanTao XiLufeng ZhengLe Guo Feng Ye Yingying Xing

Published in: Helicobacter (2021)

This study demonstrated that Helicobacter pylori can inhibit miRNA-375 expression in the stomach. Downregulated miR-375 activates the JAK2-STAT3 pathway. Activating the JAK2-STAT3 signaling pathway promotes the secretion of IL-6, IL-10, and VEGF, leading to immature differentiation of DCs and induction of gastric cancer.

Keyphrases

helicobacter pylori
signaling pathway
cell proliferation
long non coding rna
dendritic cells
helicobacter pylori infection
poor prognosis
long noncoding rna
pi k akt
regulatory t cells
endothelial cells
epithelial mesenchymal transition
vascular endothelial growth factor
induced apoptosis
binding protein