Diagnostic accuracy of a sequence-specific Mtb -DNA hybridization assay in urine: a case-control study including subclinical TB cases.
Yves TschanMohamed SasamaloHellen HizaJacques FellaySébastien GagneuxKlaus ReitherJerry HellaDamien PortevinPublished in: Microbiology spectrum (2024)
that is shed in the urine of tuberculosis patients. We present accuracy data that would fulfill the target product profile for a non-sputum test. In addition, recent epidemiological data suggested that up to 50% of individuals secreting live bacilli do not present with symptoms at the time of screening. We report, here, that the investigated index test could also detect instances of asymptomatic TB infections among household contacts.
Keyphrases
- mycobacterium tuberculosis
- pulmonary tuberculosis
- end stage renal disease
- electronic health record
- newly diagnosed
- big data
- ejection fraction
- chronic kidney disease
- single molecule
- peritoneal dialysis
- cystic fibrosis
- high throughput
- sleep quality
- atomic force microscopy
- mass spectrometry
- machine learning
- emergency department
- patient reported outcomes
- nucleic acid
- human immunodeficiency virus
- artificial intelligence
- cell free
- multidrug resistant
- hepatitis c virus
- high speed
- physical activity