Effect of Different Corticosteroid Regimens on the Outcome of Severe COVID-19-Related Acute Respiratory Failure. A Retrospective Analysis.
Michele UmbrelloPaolo FormentiStefano NespoliEleonora PisanoCecilia BoninoStefano MuttiniPublished in: Journal of clinical medicine (2021)
We were unable to find any difference between dexamethasone or methylprednisolone on the explored outcomes; high-dose boluses of corticosteroids were associated with a worse outcome. However, a subgroup of subjects was identified in whom the high-dose boluses seemed beneficial.
Keyphrases
- high dose
- respiratory failure
- stem cell transplantation
- low dose
- extracorporeal membrane oxygenation
- mechanical ventilation
- coronavirus disease
- sars cov
- drug induced
- acute respiratory distress syndrome
- liver failure
- intensive care unit
- early onset
- type diabetes
- randomized controlled trial
- weight loss
- clinical trial
- study protocol
- phase iii
- glycemic control