IDH2 regulates macrophage polarization and tumorigenesis by modulating mitochondrial metabolism in macrophages.

Sung Woo LeeSoyoon KimBokyung KimJung Bae SeongYoung-Ho ParkHong Jun LeeDong Kyu ChoiEunbyul YeomDong-Seok Lee

Published in: Molecular medicine (Cambridge, Mass.) (2024)

Our findings suggest that IDH2 deficiency inhibits M2 macrophage polarization and suppresses tumorigenesis. This study underlines the potential contribution of IDH2 expression in macrophages and tumor microenvironment remodeling, which could be useful in clinical cancer research.

Keyphrases

low grade
wild type
signaling pathway
poor prognosis
papillary thyroid
oxidative stress
squamous cell
squamous cell carcinoma
binding protein
long non coding rna
childhood cancer