Long non-coding RNA PVT1 is overexpressed in cutaneous squamous cell carcinoma and exon 2 is critical for its oncogenicity.
Chen LiChengxi SunKunal Das MahapatraPilvi RiihiläJaakko KnuutilaLiisa NissinenJan LapinsVeli-Matti KähäriBernhard HomeyEnikö SonkolyAndor PivarcsiPublished in: The British journal of dermatology (2023)
Our study reveals a previously unrecognized role for exon 2 of PVT1 in its oncogenic role and that PVT1 suppresses cellular senescence in cSCC. PVT1 may be a biomarker and therapeutic target in cSCC.